反应详情

143 g (271 mmol) of the compound from Example 62A (alternative synthesis) are dissolved in 1.43 l of tetrahydrofuran and flushed with argon. 17 g of palladium on carbon (50%, moistened with water) are added, and the mixture is then hydrogenated at RT in a hydrogen atmosphere under atmospheric pressure. The mixture is then filtered through kieselguhr, the filter cake is washed with tetrahydrofuran and the filtrate is freed from the solvent. The reaction product (134 g) is reacted further without further purification.

1. customflushed with argon
2. addition17 g of palladium on carbon (50%, moistened with water) are added
3. customis then hydrogenated at RT in a hydrogen atmosphere under atmospheric pressure
4. filtrationThe mixture is then filtered through kieselguhr
5. washthe filter cake is washed with tetrahydrofuran
6. customThe reaction product (134 g) is reacted further without further purification