Acetic Anhydride → N-(6-methyl-5-nitropyridin-2-yl)acetamide

HRID 391807Notes

Reaction equation

[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[CH3:1][C:2]1[N:7]=[C:6]([NH:8][C:12](=[O:14])[CH3:13])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 2479766-Methyl-5-nitropyridin-2-amine

Product 1

HCID 4072726N-(6-methyl-5-nitropyridin-2-yl)acetamide

Procedure

6-Methyl-5-nitro-pyridin-2-ylamine (1.0 g) was treated with acetic anhydride according to General Procedure Y to give N-(6-Methyl-5-nitro-pyridin-2-yl)-acetamide (1.2 g).

Sources & evidence

ORD record: ord-3ca8c381c28f40bfbad72be5455c6335
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08383644B2

Reaction notes

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