참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (Bromomethyl)cyclobutane | HCID 2734658 | — |
| 반응물 | N-(6-methyl-5-nitropyridin-2-yl)acetamide | HCID 4072726 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-Cyclobutylmethyl-N-(6-methyl-5-nitro-pyridin-2-yl)-acetamide | HCID 67249447 | — |
반응 단계
N-(6-Methyl-5-nitro-pyridin-2-yl)-acetamide (0.5 g) was taken in 5 mL anhydrous DMF. 3 eq of K2CO3 and 3 eq of bromomethyl-cyclobutane were added and heated at 80° C. for 24 h. Water was added to the reaction and the mixture extracted with EtOAc (2×10 mL). The organic layer was washed with water and brine and dried over Na2SO4. Solvent was concentrated and the residue was purified over silica to give N-Cyclobutylmethyl-N-(6-methyl-5-nitro-pyridin-2-yl)-acetamide LCMS (m/z): 264.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08383644B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-30a16d0c08084d26a62892e2ab2db7c3 |
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| 출처 메모 | uspto-grants-2013_02 |
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