Oxalyl chloride → 2-Methyl-1,3-oxazole-4-carbonyl chloride

HRID 391995Notes

Reaction equation

HRID 391995 reaction equation
[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([OH:9])=O)[N:6]=1.C(Cl)(=O)C([Cl:13])=O>C(Cl)Cl>[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([Cl:13])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 5394042-Methyloxazole-4-carboxylic acid

Product 1

HCID 146590622-Methyl-1,3-oxazole-4-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2-methyl-oxazole-4-carboxylic acid (30 mg) in DCM (2.0 mL), oxalyl chloride (3.0 eq) was added at room temperature. The reaction mixture was stirred for 30 minutes. Solvents were evaporated and dried under vacuo to afford 2-methyl-oxazole-4-carbonyl chloride.

Workup

  1. customSolvents were evaporated
  2. customdried under vacuo

Sources & evidence

ORD record
ord-bde29160a20a4a1b8dd073b36f0b7c8c
Source dataset
uspto-grants-2013_02
Patent number
US08383644B2

Reaction notes

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