Oxalyl chloride → Dimethyl-1,3-oxazole-5-carbonyl chloride

HRID 391997Notes

Reaction equation

HRID 391997 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.C(Cl)(=O)C([Cl:14])=O>C(Cl)Cl>[CH3:1][C:2]1[O:3][C:4]([C:8]([Cl:14])=[O:10])=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 1132979Dimethyl-1,3-oxazole-5-carboxylic acid

Product 1

HCID 12336332Dimethyl-1,3-oxazole-5-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2,4-dimethyl-oxazole-5-carboxylic acid (30 mg) in DCM (2.0 mL), oxalyl chloride (3.0 eq) was added at room temperature. The reaction mixture was stirred for 30 minutes. Solvents were evaporated and dried under vaccuo to afford 2,4-dimethyl-oxazole-5-carbonyl chloride.

Workup

  1. customSolvents were evaporated
  2. customdried under vaccuo

Sources & evidence

ORD record
ord-326750fd2a7e4eabb6511a9907fdbeda
Source dataset
uspto-grants-2013_02
Patent number
US08383644B2

Reaction notes

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