反应详情

10.65 g of N-methylglutamic acid was placed in a 250 ml round-bottom flask, and 100 ml of water was added to the flask and stirred by using a magnetic stirrer for 30 minutes. Then, 6.38 g of concentrated sulfuric acid (concentration: 98%) was slowly dropped into the flask under stirring, and stirred for additional 2 hours after dropping. After the reaction, the reaction solution was concentrated, azeotroped with toluene to further remove the water and dried under vacuum to obtain 16.5 g of N-methylglutamic acid sulfate as yellow oil (Yield: 97.7%).

1. customfor 30 minutes
2. stirringunder stirring
3. stirringstirred for additional 2 hours
4. customAfter the reaction
5. concentrationthe reaction solution was concentrated
6. customazeotroped with toluene
7. customto further remove the water
8. customdried under vacuum