Sulfuric Acid → HCID 86639893, compound

HRID 39210Notes

Reaction equation

HRID 39210 reaction equation
[CH3:1][NH:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][C:6]([OH:8])=[O:7].[S:12](=[O:16])(=[O:15])([OH:14])[OH:13]>O>[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].[CH3:1][NH:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 439377N-methyl-L-glutamic acid

Product 1

HCID 86639893HCID 86639893, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10.65 g of N-methylglutamic acid was placed in a 250 ml round-bottom flask, and 100 ml of water was added to the flask and stirred by using a magnetic stirrer for 30 minutes. Then, 6.38 g of concentrated sulfuric acid (concentration: 98%) was slowly dropped into the flask under stirring, and stirred for additional 2 hours after dropping. After the reaction, the reaction solution was concentrated, azeotroped with toluene to further remove the water and dried under vacuum to obtain 16.5 g of N-methylglutamic acid sulfate as yellow oil (Yield: 97.7%).

Workup

  1. customfor 30 minutes
  2. stirringunder stirring
  3. stirringstirred for additional 2 hours
  4. customAfter the reaction
  5. concentrationthe reaction solution was concentrated
  6. customazeotroped with toluene
  7. customto further remove the water
  8. customdried under vacuum

Sources & evidence

ORD record
ord-7e785c72c2ab42aea1a644c10c35ba43
Source dataset
uspto-grants-2013_09
Patent number
US08524895B2

Reaction notes

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