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Pyridine → 3-(2-Bromoethyl)-7-methoxybenzofuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 3-(2-Hydroxyethyl)-7-methoxybenzofuran | HCID 22662935 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(2-Bromoethyl)-7-methoxybenzofuran | HCID 22662937 | 52.1% |
反応手順
This compound was prepared by the same method as for intermediate 25, using 4.15 g (21.6 mmol) of 2-(7-methoxybenzofuran-3-yl)-ethanol, 6.8 g (25.9 mmol) of triphenylphosphine, 1.34 mL (25.9 mmol) of bromine, and 3.5 mL (43.2 mmol) of pyridine in 70 mL of CH2Cl2, to afford 2.87 g (52%) of the title compound after flash chromatography on SiO2 (25% CH2Cl2/hexanes to 100% CH2Cl2 gradient): MS (ESI) m/z 254 [M]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06800637B2 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-2f3a75522b294378b020cd0f92905c72 |
| 出典メモ | uspto-grants-2004_10 |