Sodium Cyanide → 3-(7-Methoxybenzofuran-3-yl)-propionitrile

HRID 392153Notes

Reaction equation

HRID 392153 reaction equation
Br[CH2:2][CH2:3][C:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([O:13][CH3:14])[C:7]=2[O:6][CH:5]=1.[C-:15]#[N:16].[Na+]>>[CH3:14][O:13][C:12]1[C:7]2[O:6][CH:5]=[C:4]([CH2:3][CH2:2][C:15]#[N:16])[C:8]=2[CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 8929Sodium CyanideHCID 226629373-(2-Bromoethyl)-7-methoxybenzofuran

Product 1

HCID 226629533-(7-Methoxybenzofuran-3-yl)-propionitrileYield 97.2%

Procedure

This compound was prepared by the same method as for intermediate 27, using 2.87 g (11.25 mmol) of 3-(2-bromoethyl)-7-methoxybenzofuran and 1.1 g (22.5 mmol) of sodium cyanide, to afford 2.2 g (97%) of the title compound: MS (ESI) m/z 201 [M]+.

Sources & evidence

ORD record
ord-4e9a2ac44dad4b1eac666cc11dea3c56
Source dataset
uspto-grants-2004_10
Patent number
US06800637B2

Reaction notes

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