Cyclopropylamine hydrochloride → 2-Cyclopropylamino-6,7-dimethoxy-4-(3-nitrophenyl)quinazoline

HRID 392168Notes

Reaction equation

HRID 392168 reaction equation
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:9]2[C:4](=[CH:5][C:6]([O:23][CH3:24])=[C:7]([O:21][CH3:22])[CH:8]=2)[N:3]=1.Cl.[CH:26]1([NH2:29])[CH2:28][CH2:27]1>>[CH:26]1([NH:29][C:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=3)[C:9]3[C:4](=[CH:5][C:6]([O:23][CH3:24])=[C:7]([O:21][CH3:22])[CH:8]=3)[N:3]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 11708049Cyclopropylamine hydrochlorideHCID 121503982-Chloro-6,7-dimethoxy-4-(3-nitrophenyl)quinazoline

Product 1

HCID 121504032-Cyclopropylamino-6,7-dimethoxy-4-(3-nitrophenyl)quinazolineYield 25.3%

Procedure

Starting from 500 mg 2-chloro-6,7-dimethoxy-4-(3-nitrophenyl)quinazoline and 414 mg cyclopropylamine hydrochloride, 134 mg of the title compound was obtained in the same manner as in Production Example 4.

Sources & evidence

ORD record
ord-9266999a06704d8c817963b96dae6414
Source dataset
uspto-grants-2004_10
Patent number
US06800644B2

Reaction notes

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