Methylamine → HCID 12150412, compound

HRID 392170Notes

Reaction equation

HRID 392170 reaction equation
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]=[O:19])[CH:13]=2)[C:9]2[C:4](=[CH:5][C:6]([O:22][CH3:23])=[C:7]([O:20][CH3:21])[CH:8]=2)[N:3]=1.[CH3:24][NH2:25]>CO>[CH3:21][O:20][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[O:22][CH3:23])[N:3]=[C:2]([NH:25][CH3:24])[N:11]=[C:10]2[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]=[O:19])[CH:13]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 12150410HCID 12150410, compound

Product 1

HCID 12150412HCID 12150412, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Starting from 1.50 g of 2-chloro-6,7-dimethoxy-4-(3-formylphenyl)quinazoline and 15 ml of 40% methylamine in methanol, 1.00 g of the title compound was obtained as yellow crystals in the same manner as in Production Example 8.

Sources & evidence

ORD record
ord-2eca15ed51aa4a07a99720f085509a19
Source dataset
uspto-grants-2004_10
Patent number
US06800644B2

Reaction notes

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