反应详情

A solution of 3-methyl-indazole-6-carboxylic acid (1.57 g, Reference Example 45) in methanol (75 ml) was treated with hydrogen chloride gas for 10 minutes. The reaction mixture was stirred for 12 hours at room temperature then evaporated. The residue was partitioned between ethyl acetate (50 ml) and saturated sodium bicarbonate solution (50 ml). The combined extracts were dried over sodium sulphate then evaporated. The residue was washed with hexane to give the title compound (1.56 g) which was used without further purification.

1. customthen evaporated
2. customThe residue was partitioned between ethyl acetate (50 ml) and saturated sodium bicarbonate solution (50 ml)
3. dry with materialThe combined extracts were dried over sodium sulphate
4. customthen evaporated
5. washThe residue was washed with hexane