Ammonia → 6-Amino-3-methoxy-2-pyrazinecarboxamide

HRID 392304Notes

Reaction equation

HRID 392304 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8](OC)=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1.[NH3:14]>CO>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH2:14])=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22662843Methyl 6-amino-3-methoxy-2-pyrazinecarboxylate

Product 1

HCID 226628026-Amino-3-methoxy-2-pyrazinecarboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 70 mL of methanol was dissolved 3.5 g of methyl 6-amino-3-methoxy-2-pyrazinecarboxylate. After introducing gaseous ammonia into the solution to prepare a saturated solution, and the solution was stirred at room temperature for 14 hours. By removing the solvent from the reaction mixture under reduced pressure, 3.1 g of 6-amino-3-methoxy-2-pyrazinecarboxamide was obtained as a solid product.

Workup

  1. customto prepare a saturated solution
  2. customBy removing the solvent from the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-654326750ebb43cc8c006ba7c4e18125
Source dataset
uspto-grants-2004_10
Patent number
US06800629B2

Reaction notes

Loading…