Ammonia → 6-Amino-3-methoxy-2-pyrazinecarboxamide

Participants

Reaction Steps

In 70 mL of methanol was dissolved 3.5 g of methyl 6-amino-3-methoxy-2-pyrazinecarboxylate. After introducing gaseous ammonia into the solution to prepare a saturated solution, and the solution was stirred at room temperature for 14 hours. By removing the solvent from the reaction mixture under reduced pressure, 3.1 g of 6-amino-3-methoxy-2-pyrazinecarboxamide was obtained as a solid product.

Provenance & Evidence