Ammonia → HCID 135674105, compound

HRID 392311Notes

Reaction equation

HRID 392311 reaction equation
[O:1]=[C:2]1[NH:7][CH:6]=[CH:5][N:4]=[C:3]1[C:8]#[N:9].Cl.[NH3:11]>CO>[O:1]=[C:2]1[NH:7][CH:6]=[CH:5][N:4]=[C:3]1[C:8](=[NH:11])[NH2:9]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 129137633-Oxo-3,4-dihydropyrazine-2-carbonitrile

Product 1

HCID 135674105HCID 135674105, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

In 33 ml of methanol was dissolved 1.1 g of 3-oxo-3,4-dihydro-2-pyrazinecarbonitrile synthesized according to the description of J. Heterocycl. Chem., Vol. 19, Pages 1,397-1,402 (1982). While cooling the solution with ice, gaseous hydrogen chloride was introduced until saturation, after which the solution was stirred at the same temperature as above for 8 hours. The solvent was removed under reduced pressure, the residue thus obtained and dissolved in 55 ml of a 7 mol/L solution of ammonia in methanol at an ice-cooled temperature, and the solution thus obtained was stirred at the same temperature as above for 5 minutes. The solid product formed was collected by filtration to obtain 1.1 g of 3-oxo-3,4-dihydro-2-pyrazinecarboximidamide as a light yellow-colored solid product.

Workup

  1. customsynthesized
  2. additionwas introduced until saturation
  3. customThe solvent was removed under reduced pressure
  4. customthe residue thus obtained
  5. temperaturecooled temperature
  6. customthe solution thus obtained
  7. stirringwas stirred at the same temperature as above for 5 minutes
  8. customThe solid product formed
  9. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-b7f83cb9b6c54596aa57078c71f6063f
Source dataset
uspto-grants-2004_10
Patent number
US06800629B2

Reaction notes

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