反应详情

温度

80 °C

In 5 ml of toluene was dissolved 0.5 g f 3,6-difluoro-2-pyrazinecarbonitrile. After adding 0.41 mL of benzyl alcohol and 0.74 mL of triethylamine successively, the mixture thus obtained was stirred at 80° C. for one hour. The reaction mixture was cooled to room temperature and then purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=10:1] to obtain 0.58 g of 3-(benzyloxy)-6-fluoro-2-pyrazinecarbonitrile as a white-colored solid product.

1. customthe mixture thus obtained
2. temperatureThe reaction mixture was cooled to room temperature
3. custompurified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=10:1]