反应详情

温度

5 °C

A solution of 3-(2-methoxyphenoxy)aniline (269 mg, 1.25 mmol) and pyridine-3-carboxaldehyde (107 mg, 1.00 mmol) was refluxed in methanol (2.5 mL) for 2 h, then cooled on an ice bath to 5° C. Sodium borohydride (95 mg, 2.5 mmol) was added and the mixture was warmed to room temperature, stirred for 2 h, concentrated in vacuo, and taken up in dichloromethane. The resultant suspension was filtered, the filtrate concentrated in vacuo, and the residue chromatographed on silica gel (eluted with 2% methanol/dichloromethane) to give N-(3-(2-methoxyphenoxy)phenyl)pyrid-3-ylmethylamine.

1. temperaturethe mixture was warmed to room temperature
2. concentrationconcentrated in vacuo
3. filtrationThe resultant suspension was filtered
4. concentrationthe filtrate concentrated in vacuo
5. customthe residue chromatographed on silica gel (eluted with 2% methanol/dichloromethane)