Ethanesulfonyl chloride → HCID 23521718, compound

HRID 392409Notes

Reaction equation

HRID 392409 reaction equation
[C:1]([C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][CH2:13][C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[CH:8][CH:7]=1)#[N:2].[CH2:24]([S:26](Cl)(=[O:28])=[O:27])[CH3:25]>>[C:1]([C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[O:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]([CH2:13][C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[S:26]([CH2:24][CH3:25])(=[O:28])=[O:27])=[CH:10][CH:11]=1)#[N:2]

Participants

3

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 22663874HCID 22663874, compound

Product 1

HCID 23521718HCID 23521718, compound

Procedure

Using the method of Example 342 using N-(4-(2-cyanophenoxy)phenyl)pyridin-3-ylmethylamine and ethanesulfonyl chloride (Aldrich) and purifying via preparative HPLC eluting with 98:2 to 96:4 DCM/MeOH. Anal Calcd for C21H19N3O3S.0.2H2O: C, 63.52; H, 4.92; N, 10.58. Found: C, 63.51; H, 4.79; N, 10.55. MS found 394.0 [M+H]+

Workup

  1. custompurifying via preparative HPLC
  2. washeluting with 98:2 to 96:4 DCM/MeOH

Sources & evidence

ORD record
ord-26c16c92a2884acfb57e33b9120adbc1
Source dataset
uspto-grants-2004_10
Patent number
US06800651B2

Reaction notes

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