Ethanesulfonyl chloride → HCID 23521720, compound

HRID 392417Notes

Reaction equation

HRID 392417 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:7][CH:6]=1.[CH2:23]([S:25](Cl)(=[O:27])=[O:26])[CH3:24]>>[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([N:11]([CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[S:25]([CH2:23][CH3:24])(=[O:27])=[O:26])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 69880868HCID 69880868, compound

Product 1

HCID 23521720HCID 23521720, compound

Procedure

Using the method of Example 342 using N-(4-(2-fluorophenoxy)phenyl)pyrid-3-ylmethylamine and ethanesulfonyl chloride (Aldrich) and purifying via preparative HPLC eluting with 99:1 to 97:3 DCM/MeOH gave the title compound. Anal Calcd for C20H19FN2O3S.0.2H2O: C, 61.59; H, 5.01; N, 7.18. Found: C, 61.65; H, 4.85; N, 7.14. MS found 387.1 [M+H]+

Workup

  1. custompurifying via preparative HPLC
  2. washeluting with 99:1 to 97:3 DCM/MeOH

Sources & evidence

ORD record
ord-4354e2707ea647c3a4a82669c60a6308
Source dataset
uspto-grants-2004_10
Patent number
US06800651B2

Reaction notes

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