Sulfuryl chloride → HCID 86762023, compound

HRID 39247Notes

Reaction equation

HRID 39247 reaction equation
S(Cl)([Cl:4])(=O)=O.[C:6](=[O:35])([O:10][CH:11]([O:13][C:14](=[O:34])[CH2:15][CH2:16][CH:17]([P:26]([O:31][CH2:32][CH3:33])([O:28][CH2:29][CH3:30])=[O:27])[P:18]([O:23][CH2:24][CH3:25])([O:20][CH2:21][CH3:22])=[O:19])[CH3:12])SCC>C(Cl)Cl>[CH2:21]([O:20][P:18]([CH:17]([P:26]([O:31][CH2:32][CH3:33])([O:28][CH2:29][CH3:30])=[O:27])[CH2:16][CH2:15][C:14]([O:13][CH:11]([O:10][C:6]([Cl:4])=[O:35])[CH3:12])=[O:34])([O:23][CH2:24][CH3:25])=[O:19])[CH3:22]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 86762024S-Ethyl O-1-(4,4-bis(diethylphosphono)butanoyloxy)ethyl carbonothioate

Product 1

HCID 86762023HCID 86762023, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

Sulfuryl chloride (78 μL, 0.96 mmol) was added drop-wise to a solution of 23 (237 mg, 0.48 mmol) in 10 mL of CH2Cl2 cooled to 0° C. The solution was stirred for 2 h. The solvent was removed under reduced pressure to afford chloroformate 24 and which was used for the next reaction without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-6e28a8d386fe456a9190bdf5a12e38f0
Source dataset
uspto-grants-2013_09
Patent number
US08524691B2

Reaction notes

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