HCID 22662878, compound → 4-[(1H-Imidazol-1-yl)methyl]piperidine

HRID 392496Notes

Reaction equation

HRID 392496 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[N:15]1([CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:19]=[CH:18][N:17]=[CH:16]1

Participants

4

Reactant 1

HCID 22662878HCID 22662878, compound

Product 1

HCID 226629174-[(1H-Imidazol-1-yl)methyl]piperidine

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The title compound(0.187 g, 0.705 mmoles) from Step C was stirred in 4N HCl in dioxane (20 mL) for 2 h and then evaporated to dryness to give the title compound which was used to couple with the tricyclic acid.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-60f2247b86574feab9420fe583425076
Source dataset
uspto-grants-2004_10
Patent number
US06800636B2

Reaction notes

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