反应详情

温度

0 °C

The title compound from Step B above (1.7 g, 6.72 mmoles) and triethylamine (1.1 g, 10.87 mmoles) were dissolved in CH2Cl2 (20 mL) and the mixture was stirred under nitrogen at 0° C. Methanesulfonylchloride (1.1 g, 9.6 mmoles) was added and the solution was stirred at room temperature for 2 h. The solution was diluted with CH2Cl2 and washed with saturated aqueous sodium bicarbonate, water and dried (MgSO4), filtered and evaporated to dryness to give the title compound (2.32 g, 99%). FABMS (M+1)=332.

1. stirringthe solution was stirred at room temperature for 2 h
2. washwashed with saturated aqueous sodium bicarbonate, water
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customevaporated to dryness