Trifluoroacetic acid → HCID 86655574, compound

HRID 39250Notes

Reaction equation

HRID 39250 reaction equation
C[O:2][CH:3]([O:31]C)[CH2:4][N:5]([C:10](=[O:30])[CH2:11][CH2:12][CH:13]([P:22]([CH2:27][CH:28]=[CH2:29])([CH2:24][CH:25]=[CH2:26])=[O:23])[P:14]([CH2:19][CH:20]=[CH2:21])([CH2:16][CH:17]=[CH2:18])=[O:15])[CH2:6][C:7](O)=[O:8].C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:8]=[CH:7][CH2:6][N:5]([C:10](=[O:30])[CH2:11][CH2:12][CH:13]([P:22]([CH2:27][CH:28]=[CH2:29])([CH2:24][CH:25]=[CH2:26])=[O:23])[P:14]([CH2:16][CH:17]=[CH2:18])([CH2:19][CH:20]=[CH2:21])=[O:15])[CH2:4][C:3]([OH:31])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86655575HCID 86655575, compound

Product 1

HCID 86655574HCID 86655574, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 39 (120 mg, 0.217 mmol) was dissolved in 5 mL of CH2Cl2 and 2.5 mL of TFA (containing 6% H2O) was added. The mixture was stirred for 30 min at room temperature and was then concentrated in vacuo to give the product 40 that was used as such in the next step. 1H NMR (400 MHz, CDCl3) δ 2.29 (m, 2H), 2.64 (m, 2H), 2.86 (m, 1H), 4.04 (bs, 2H), 4.16 (d, J=5.3 Hz, 2H), 4.60 (m, 8H), 4.74 (s, 2H), 5.23-5.27 (m, 4H), 5.35-5.40 (m, 4H), 5.90-6.00 (m, 4H), 9.58 (s, 1H).

Workup

  1. concentrationwas then concentrated in vacuo

Sources & evidence

ORD record
ord-eb476a609cee474e9c7ba9669c8c1bea
Source dataset
uspto-grants-2013_09
Patent number
US08524691B2

Reaction notes

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