Trifluoroacetic acid → HCID 58352676, compound

HRID 39255Notes

Reaction equation

HRID 39255 reaction equation
C[O:2][CH:3](OC)[CH2:4][O:5][C:6]([CH2:8][NH:9][C:10](=[O:18])[O:11][CH2:12][O:13][C:14](=[O:17])[CH2:15][CH3:16])=[O:7].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:3]([CH2:4][O:5][C:6]([CH2:8][NH:9][C:10](=[O:18])[O:11][CH2:12][O:13][C:14](=[O:17])[CH2:15][CH3:16])=[O:7])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86655576HCID 86655576, compound

Product 1

HCID 58352676HCID 58352676, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 55 (268 mg, 0.91 mmol) was dissolved in 10 mL of CH2Cl2 and 5 mL of TFA (containing 5% H2O) was added. The mixture was stirred for 30 min at room temperature. The solution was then concentrated to dryness in vacuo to give the product 56 that was used immediately for the next step. 1H NMR (400 MHz, CDCl3) δ 1.15 (t, J=7.43 Hz, 3H), 2.40 (q, J=7.43 Hz, 2H), 4.16 (d, J=5.47 Hz, 2H), 4.78 (s, 2H), 5.75 (s, 2H), 6.30 (bs, 1H), 9.60 (s, 1H).

Workup

  1. concentrationThe solution was then concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-05cdcc8563f3473ba99f7f01c7fbf2ff
Source dataset
uspto-grants-2013_09
Patent number
US08524691B2

Reaction notes

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