Iodine → HCID 178516519, compound

HRID 392680Notes

Reaction equation

HRID 392680 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][N:3]=1.C([O-])([O-])=O.[K+].[K+].[I:15]I.OS([O-])(=O)=O.[K+]>O>[OH:1][C:2]1[C:7]([I:15])=[C:6]([OH:8])[CH:5]=[CH:4][N:3]=1

Participants

6

Reactant 4

HCID 807IodineHCID 11430Potassium CarbonateHCID 516920Potassium bisulfateHCID 178516518HCID 178516518, compound

Product 1

HCID 178516519HCID 178516519, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2,4-dihydroxypyridine (1.0 eq), K2CO3 (1.0 eq), and water was stirred at 100° C. so that it became homogeneous. With continued stirring and heating, I2 (1.0 eq) was added in portions, causing the evolution of gas. When the solid I2 was consumed, the mixture was cooled and acidified with aqueous KHSO4 (1.0 eq), generating a precipitate. The precipitate was collected by filtration, rinsed with water, and stored under high vacuum, to give 2,4-dihydroxy-3-iodopyridine.

Workup

  1. stirringWith continued stirring
  2. temperatureheating
  3. customWhen the solid I2 was consumed
  4. temperaturethe mixture was cooled
  5. filtrationThe precipitate was collected by filtration
  6. washrinsed with water

Sources & evidence

ORD record
ord-20f24aedfaa64334b81c5857dc084546
Source dataset
uspto-grants-2004_10
Patent number
US06803370B2

Reaction notes

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