5-Ethyl-1,3,4-oxadiazol-2-amine → N-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-2,2-diphenyl-acetamide

HRID 392726Notes

Reaction equation

HRID 392726 reaction equation
CC1C=[C:5](C)[N:4]([C:8](=[O:22])[CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)N=1.[CH2:23]([C:25]1[O:29]C(N)=[N:27][N:26]=1)[CH3:24]>>[CH2:23]([C:25]1[O:29][C:5]([NH:4][C:8](=[O:22])[CH:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[N:27][N:26]=1)[CH3:24]

Participants

3

Reactant 2

HCID 3434875-Ethyl-1,3,4-oxadiazol-2-amineHCID 7743981-(3,5-Dimethylpyrazol-1-yl)-2,2-diphenylethanone

Product 1

HCID 22661073N-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-2,2-diphenyl-acetamide

Procedure

The title compound, white solid, m.p. 123-125° C. and MS: m/e=308.2 (M+H+) was prepared in accordance with the general method of example 48a from l-(3,5-dimethyl-pyrazol-1-yl)-2,2-diphenyl-ethanone and 5-ethyl-[1,3,4]oxadiazol-2-ylamine. The 1-(3,5-dimethyl-pyrazol-1-yl)-2,2-diphenyl-ethanone, white solid, m.p. 91-92° C. and MS: m/e=291.2 (M+H+) used in the above reaction was prepared in accordance with the general method of example 48c from 2,2-diphenylacetic acid hydrazide [Chem. Zentralblatt. 100, 2414(1929)] and acetylacetone.

Sources & evidence

ORD record
ord-039e57898f08497c9d15b3a70533b7d9
Source dataset
uspto-grants-2004_10
Patent number
US06803381B1

Reaction notes

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