反应详情

A solution of (S)-(+)-2,2-dimethyl-5-oxo-1,3-dioxolane-4-acetic acid, t-butyldimethylsilyl ester (20.9 g, 72.4 mmol) in carbon tetrachloride (200 ml) was treated with N-bromosuccinimide (14.18 g, 79.6 mmol) and 2,2′-azobisisobutyronitrile (0.30 g) and the resulting mixture was heated under reflux while irradiating with a 500 W lamp. After ˜5 min., a mild exothermic reaction was observed and the mixture was heated for an additional 5 min. The reaction mixture was then cooled in an ice bath and the floating succinimide was filtered and washed with a small amount of carbon tetrachloride. The filtrate was used immediately as such for the next step. 1H NMR (400 MHz, CDCl3) δ: 0.27 (s, 3), 0.28 (s, 3), 0.94 (s, 9), 1.66 (s, 3), 1.84 (s, 3), 3.62 (m, 2).

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux
3. customwhile irradiating with a 500 W lamp
4. customa mild exothermic reaction
5. temperaturethe mixture was heated for an additional 5 min
6. temperatureThe reaction mixture was then cooled in an ice bath
7. filtrationthe floating succinimide was filtered
8. washwashed with a small amount of carbon tetrachloride