HCID 3757313, compound → 3-(4-Fluoro-benzyloxy)-benzoic acid

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Reaction Steps

Saponification of methyl 3-(4-fluorobenzyloxy)-benzoate as described in the preparation of Intermediate 1B gave the title acid as white needles: mp 145-146° C. (ethyl acetate). 1HNMR 400 MHz (CDCl3) δ (ppm): 5.11 (2H, s, OCH2), 7.12 (2H, m, aromatics), 7.24 (1 H, m, aromatics), 7.45 (3 H, m, aromatics), 7.75 (2H, m, aromatics). Anal. Calcd for C14H11FO3: C, 68.29; H, 4.50. Found: C, 68.39; H, 4.43.

Provenance & Evidence