HCID 3757313, compound → 3-(4-Fluoro-benzyloxy)-benzoic acid

HRID 392823Notes

Reaction equation

HRID 392823 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[C:11]([O:13]C)=[O:12])=[CH:4][CH:3]=1>C(OCC)(=O)C>[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 3757313HCID 3757313, compound

Product 1

HCID 9644033-(4-Fluoro-benzyloxy)-benzoic acid

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Saponification of methyl 3-(4-fluorobenzyloxy)-benzoate as described in the preparation of Intermediate 1B gave the title acid as white needles: mp 145-146° C. (ethyl acetate). 1HNMR 400 MHz (CDCl3) δ (ppm): 5.11 (2H, s, OCH2), 7.12 (2H, m, aromatics), 7.24 (1 H, m, aromatics), 7.45 (3 H, m, aromatics), 7.75 (2H, m, aromatics). Anal. Calcd for C14H11FO3: C, 68.29; H, 4.50. Found: C, 68.39; H, 4.43.

Workup

  1. customgave the title acid as white needles

Sources & evidence

ORD record
ord-fe68c54c86504a47898cb8425ea2f76d
Source dataset
uspto-grants-2004_10
Patent number
US06803378B2

Reaction notes

Loading…