反应详情

温度

40 °C

A suspension of compound 6 (0.330 g, 1.04 mmol) in DMF (2.4 mL) and cesium carbonate (339 mg, 1.04 mmol) was heated at 40° C. until almost clear. Compound 14 (356 mg, 1.14 mmol) was added in portions. The reaction mixture was stirred at rt for 18 h. The mixture was concentrated on a rotary evaporator. The residue was washed with water and collected by filtration. This material was purified by column chromatography (silica gel, 50% to 100% hexane/ethyl acetate (v/v) to give compound 15 (0.55 g, 100% yield). ESI-MS m/e 548 (M=1).

1. concentrationThe mixture was concentrated on a rotary evaporator
2. washThe residue was washed with water
3. filtrationcollected by filtration
4. customThis material was purified by column chromatography (silica gel, 50% to 100% hexane/ethyl acetate (v/v)