反应详情

A mixture of 4-(bromomethyl)benzimidazole-1-carboxylic acid, 1,1-dimethylethyl ester (1.08 g, 3.5 mmol), sodium azide (240 mg, 3.7 mmol), and sodium iodide (5 mg) in acetone (10 mL) was heated at reflux for 66 h. The solvent was evaporated and dichloromethane was added. The solution was washed with dilute aqueous sodium hydrogen carbonate, dried (Na2SO4), filtered and evaporated to give 4-(azidomethyl)benzimidazole-1-carboxylic acid, 1,1-dimethylethyl ester (800 mg, 84%).

1. temperaturewas heated
2. temperatureat reflux for 66 h
3. customThe solvent was evaporated
4. additiondichloromethane was added
5. washThe solution was washed with dilute aqueous sodium hydrogen carbonate
6. dry with materialdried (Na2SO4)
7. filtrationfiltered
8. customevaporated