反应详情

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

1. temperaturethe solution was heated for 15 hours
2. temperatureunder reflux
3. extractionthe organic layer was extracted with chloroform
4. washAfter washing the
5. extractionextract three times with water
6. customthe chloroform was removed by distillation
7. customThe residue was recrystallized from a mixture of acetone and hexane