Acetic Anhydride → HCID 86759544, compound

HRID 393156Notes

Reaction equation

[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5](=[O:9])[CH:6]([CH3:8])[CH3:7].[CH:13]([O-])([O-])[O:14][CH2:15][CH3:16].C(OC(=O)C)(=O)C>>[CH2:15]([O:14][CH:13]=[C:4]([C:5](=[O:9])[CH:6]([CH3:8])[CH3:7])[C:3](=[O:10])[C:2]([F:11])([F:12])[F:1])[CH3:16]

Participants

Reactant 3

HCID 7918Acetic Anhydride

HCID 1601912,4-Hexanedione, 1,1,1-trifluoro-5-methyl-

HCID 53630039Ethylorthoformate

Product 1

HCID 86759544HCID 86759544, compoundYield 67%

Procedure

A mixture comprising 213 g (1.17 mol) of 1,1,1-trifluoro-5-methyl-2,4-hexanedione, 242 g (1.64 mol) of ethyl orthoformate and 166 g (1.63 mol) of acetic anhydride, was heated and refluxed for 6 hours. The solvent was distilled off under reduced pressure to obtain 146 g (yield: 67%) of 3-ethoxymethylene-1,1,1-trifluoro-5-methyl-2,4-hexanedione.

Workup

temperaturerefluxed for 6 hours
distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record: ord-c6489a92ee5f47b3a4043b0ee3b2fd42
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06806230B1

Reaction notes

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