反应详情

A mixture of 0.917 g of 2-amino-5-(2-bromoethyl)-4-(4-fluorophenyl)thiazole hydrobromide, 0.511 g of 4-(6-fluorobenzofuran-3-yl)piperidine hydrochloride, 1.5 ml of diisopropylethylamine and 3 ml of methanol was stirred with heating under reflux for 12 hours. The reaction mixture was cooled to room temperature and then poured into water, followed by extraction with chloroform. The extract solution was dried over magnesium sulfate, and then the solvent was distilled off under reduced pressure, after which ether was added to the residue and the crystals were collected by filtration. The crystals were recrystallized from ethanol to obtain 0.57 g of 2-amino-4-(4-fluorophenyl)-5-[2-[4-(6-fluorobenzofuran-3-yl)piperidin-1-yl]ethyl]thiazole.

1. temperaturewith heating
2. temperatureunder reflux for 12 hours
3. extractionfollowed by extraction with chloroform
4. dry with materialThe extract solution was dried over magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure
6. additionafter which ether was added to the residue
7. filtrationthe crystals were collected by filtration
8. customThe crystals were recrystallized from ethanol