HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 22649084, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-butyl 2-aminopiperidine-1-carboxylate | HCID 4112359 | — |
| Reactant | 5-(Benzylthio)-2-bromo-7-chlorothiazolo[4,5-d]pyrimidine | HCID 22052038 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22649084 | HCID 22649084 | — |
Reaction Steps
A solution of the product from Example 219 (0.3 g) in tetrahydrofuran (2 ml) containing 4 amino-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (0. 161 g) and N-ethyldiisopropylamine (0.5 ml) was stirred for 16 hours before evaporating to dryness. The residue was taken into dichloromethane (30 ml) and trifluoroacetic acid (3 ml) added. The solution was stirred for 30 minutes then concentrated to give the title compound (310 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06806273B1 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-14b5a1a35c074595a0e564224343a045 |
| Source note | uspto-grants-2004_10 |