反应详情

温度

75 °C

A well stirred suspension of 6-(cyclopentyloxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde 2-oxide (200 mg, 0.671 mmol) in 48% aqueous hydrobromic acid (10 mL) was heated to 70-80° C. for 2-3 hours. The reaction mixture was cooled to room temperature and diluted with water (50 mL) and was made alkaline (pH=9-10) by means of a 10% aqueous solution of sodium hydroxide. It was then washed with ethyl acetate (2×25 mL). The aqueous layer was then acidified with acetic acid (pH=4-5) and stirred at 10-15° C. for 30-40 minutes. The solid obtained was filtered and dried to afford 6-hydroxy[1]benzofuro[3,2-c]pyridine-9-carbaldehyde-2-oxide (Yield=80-90%).

1. temperatureThe reaction mixture was cooled to room temperature
2. washIt was then washed with ethyl acetate (2×25 mL)
3. stirringstirred at 10-15° C. for 30-40 minutes
4. customThe solid obtained
5. filtrationwas filtered
6. customdried