Potassium → HCID 9813018, compound

HRID 393347Notes

Reaction equation

HRID 393347 reaction equation
BrC1CN(C(CC)C(N)=O)C(=O)C1C#C.Br[C:17](Br)=[CH:18][CH:19]1[CH2:23][N:22]([CH:24]([CH2:28][CH3:29])[C:25]([NH2:27])=[O:26])[C:21](=[O:30])[CH2:20]1.[K]>C1COCC1>[C:18]([CH:19]1[CH2:23][N:22]([CH:24]([CH2:28][CH3:29])[C:25]([NH2:27])=[O:26])[C:21](=[O:30])[CH2:20]1)#[CH:17]

Participants

5

Reactant 3

HCID 5462222PotassiumHCID 9946598HCID 9946598, compoundHCID 22387035HCID 22387035, compound

Product 1

HCID 9813018HCID 9813018, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Alternatively, 2-(4-bromo-ethynyl-2-oxo-1-pyrrolidinyl)butanamide 267 is obtained by reacting 2-[4-(2,2-dibromovinyl)-2-oxo-1-pyrrolidinyl]butanamide 47 with two equivalent of potassium tertbutoxyde in THF at low temperature (−50° C. to 0° C.).

Workup

  1. customat low temperature (−50° C. to 0° C.)

Sources & evidence

ORD record
ord-8459276a0f0441b3a2fd0a529bad94ab
Source dataset
uspto-grants-2004_10
Patent number
US06806287B2

Reaction notes

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