1-Chloromethyl-2-methylnaphthalene → N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide

HRID 393380Notes

Reaction equation

HRID 393380 reaction equation
FC(F)(F)C1C=C(C=C(C(F)(F)F)C=1)[CH2:6][N:7](C)[C:8](=[O:28])[C:9]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[CH:13][C:12]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:11][CH:10]=1.Cl[CH2:40][C:41]1[C:50]2[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH:44]=[CH:43][C:42]=1[CH3:51]>>[CH3:6][N:7]([CH2:40][C:41]1[C:50]2[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH:44]=[CH:43][C:42]=1[CH3:51])[C:8](=[O:28])[C:9]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[CH:13][C:12]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)=[N:11][CH:10]=1

Participants

3

Reactant 2

HCID 811061-Chloromethyl-2-methylnaphthaleneHCID 10119544N-(3,5-Bis-trifluoromethyl-benzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide

Product 1

HCID 9847336N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide

Procedure

The parent compound was obtained as a white solid in comparable yield according to the procedure described above for the preparation of N-(3,5-bis-trifluoro-methylbenzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide (Example 16, step d) using 1-chloromethyl-2-methylnaphthalene instead of 3,5-bis-trifluoromethyl-benzyl bromide.

Workup

  1. customThe parent compound was obtained as a white solid
  2. customin comparable yield

Sources & evidence

ORD record
ord-370e19bd5e454e7d9e794e905920d4be
Source dataset
uspto-grants-2004_10
Patent number
US06806370B2

Reaction notes

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