HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloromethyl-2-methylnaphthalene → N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloromethyl-2-methylnaphthalene | HCID 81106 | — |
| Reactant | N-(3,5-Bis-trifluoromethyl-benzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide | HCID 10119544 | — |
| Product | N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide | HCID 9847336 | — |
Reaction Steps
The parent compound was obtained as a white solid in comparable yield according to the procedure described above for the preparation of N-(3,5-bis-trifluoro-methylbenzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide (Example 16, step d) using 1-chloromethyl-2-methylnaphthalene instead of 3,5-bis-trifluoromethyl-benzyl bromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06806370B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-370e19bd5e454e7d9e794e905920d4be |
| Source note | uspto-grants-2004_10 |