Ammonium Hydroxide → HCID 24890788, compound

HRID 39342Notes

Reaction equation

HRID 39342 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]3[CH:12]=[N:13][N:14]=[C:7]3[C@@H:6]([CH2:15][CH3:16])[N:5]([CH:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[C:4]=2[N:3]=1.[OH-].[NH4+:23]>>[CH:17]1([N:5]2[C:4]3[N:3]=[C:2]([NH2:23])[N:11]=[CH:10][C:9]=3[N:8]3[CH:12]=[N:13][N:14]=[C:7]3[C@H:6]2[CH2:15][CH3:16])[CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 59389586(R)-7-chloro-5-cyclopentyl-4-ethyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine

Product 1

HCID 24890788HCID 24890788, compoundYield 36%

Procedure

A solution of (R)-7-chloro-5-cyclopentyl-4-ethyl-4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine (500 mg, 1.64 mmol) in ammonium hydroxide (10 ml) was heated under microwave irradiation at 140° C. for 30 minutes. The solvent was removed under reduced pressure and cold water (5 mL) was added. The resulting light brown solid was filtered under vacuum and washed with cold water to give the title compound (170 mg, 36% yield).

Workup

  1. customThe solvent was removed under reduced pressure and cold water (5 mL)
  2. additionwas added
  3. filtrationThe resulting light brown solid was filtered under vacuum
  4. washwashed with cold water

Sources & evidence

ORD record
ord-92a98c24ee5e48bcbb9f5aadfbcde2e3
Source dataset
uspto-grants-2013_09
Patent number
US08524902B2

Reaction notes

Loading…