反应详情

A solution of 1-(4-bromobutyl)cyclopentane carboxlic acid methyl ester was treated with a solution of 0.5 molar lithium cyanide in DMF (5 mmol, 10 mL) and stirred overnight at room temperature followed by heating at 75° C. for two hrs. The reaction mixture was evaporated to dryness, the residue was dissolved in ethyl acetate (30 mL) and washed with sat'd sodium bicarbonate (2×10 mL), and brine (5 mL) and dried over magnesium sulfate to give a yellow oil (860 mg). Silica gel chromtography eluting with 1:3 ethyl acetate:hexane yielded a pale oil (83%, 693 mg). LR MS (C12H19NO2): Obs mass, 227 (M+NH4), 248 (M+K).

1. temperatureby heating at 75° C. for two hrs
2. customThe reaction mixture was evaporated to dryness
3. dissolutionthe residue was dissolved in ethyl acetate (30 mL)
4. washwashed with sat'd sodium bicarbonate (2×10 mL), and brine (5 mL)
5. dry with materialdried over magnesium sulfate