2,6-Dimethyl-4-(trifluoromethyl)nicotinic acid → N-[[1-[4-(methylsulfonyl)butyl]cyclopentyl]carbonyl]-L-phenylalanine
Reaction equation
C[O:2][C:3](=[O:29])[C@H:4]([CH2:21][C:22]1[CH:27]=[CH:26][C:25](N)=[CH:24][CH:23]=1)[NH:5][C:6]([C:8]1([CH2:13][CH2:14][CH2:15][CH2:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:7].CC1C(C(O)=O)=C(C(F)(F)F)C=C(C)N=1>>[CH3:20][S:17]([CH2:16][CH2:15][CH2:14][CH2:13][C:8]1([C:6]([NH:5][C@H:4]([C:3]([OH:29])=[O:2])[CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:7])[CH2:9][CH2:10][CH2:11][CH2:12]1)(=[O:18])=[O:19]Participants
3
Procedure
4-[(2,6-Dimethyl-4-trifluoromethyl-3-pyridinyl)carbonyl]amino]-N-[[1-[4-(methylsulfonyl)butyl]cyclopentyl]carbonyl]-L-phenylalanine was prepared from 4-amino-N-[[1-[4-(methylsulfonyl)butyl]cyclopentyl]carbonyl]-L-phenylalanine methyl ester and 2,6-dimethyl-4-trifluoromethyl-3-pyridine carboxylic acid using the general procedure described in example 364.
Sources & evidence
- ORD record
- ord-be6cfc824735441bbe88a58129df44fb
- Source dataset
- uspto-grants-2004_10
- Patent number
- US06806365B2
Reaction notes
Loading…