Methylamine → HCID 22593947, compound

HRID 393558Notes

Reaction equation

HRID 393558 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]([CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([O:25][CH2:26][CH3:27])[C:22](O)=[O:23])=[CH:16][CH:15]=2)[CH2:3][CH2:2]1.[CH3:28][NH2:29]>>[CH3:28][NH:29][C:22](=[O:23])[CH:21]([O:25][CH2:26][CH3:27])[CH2:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH2:12][CH2:11][N:4]2[C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[O:1][CH2:2][CH2:3]2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 9930450HCID 9930450, compound

Product 1

HCID 22593947HCID 22593947, compoundYield 74%

Procedure

The title compound (0.23 g, 74%) was prepared as a white solid from 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxypropanoic acid (0.3 g, 0.8 mmol) obtained in example 26 and methylamine (40% solution) (2 mL) by an analogous procedure to that described in example 32. mp: 97-99° C.

Sources & evidence

ORD record
ord-e3c188f3846d472584b326c26ce1f513
Source dataset
uspto-grants-2004_10
Patent number
US06809095B2

Reaction notes

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