反应详情

A suspension of 6,7-dimethoxy-1,4-dihydroquinolin-4-one (3 g, 14 mmol), (J. Chem. Soc. 1940, 1209), in thionyl chloride (60 ml) and DMF (0.3 ml) was heated at reflux for 3 hours. Excess thionyl chloride was removed by evaporation and the residue azeotroped with toluene and washed with ether to give 4-chloro-6,7-dimethoxyquinoline hydrochloride.

1. temperaturewas heated
2. temperatureat reflux for 3 hours
3. customExcess thionyl chloride was removed by evaporation
4. customthe residue azeotroped with toluene
5. washwashed with ether