反应详情

A suspension of 7-benzyloxy-6-methoxy-1,4-dihydroquinolin-4-one (3.37 g, 13 mmol) in thionyl chloride (50 ml) and DMF (0.25 ml) was heated at reflux for 1 hour. Excess thionyl chloride was removed by evaporation and the residue azeotroped with toluene and triturated with ether, the product collected by filtration and dried under vacuum to give 7-benzyloxy-4-chloro-6-methoxyquinoline hydrochloride (3.9 g, 89%).

1. temperaturewas heated
2. temperatureat reflux for 1 hour
3. customExcess thionyl chloride was removed by evaporation
4. customthe residue azeotroped with toluene
5. customtriturated with ether
6. filtrationthe product collected by filtration
7. customdried under vacuum