反应详情

A solution of 5-((3-(3-morpholinopropoxy)-4-methoxyanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (700 mg, 1.66 mmol) in phenyl ether (5 ml) was heated at reflux for 2 minutes. After cooling, the residue was triturated with ether and acetone. The solid was collected by filtration, washed with acetone followed by ether and dried under vacuum to give 6-methoxy-7-(3-morpholinopropoxy)-1,4-dihydroquinolin-4-one (207 mg, 41%).

1. temperatureat reflux for 2 minutes
2. temperatureAfter cooling
3. customthe residue was triturated with ether and acetone
4. filtrationThe solid was collected by filtration
5. washwashed with acetone
6. customdried under vacuum