反应详情

A solution of 6-methoxy-7-(3-morpholinopropoxy)-1,4-dihydroquinolin-4-one (200 mg, 0.63 mmol) in thionyl chloride (10 ml) containing DMF (3 drops) was heated at reflux for 1 hour. After removal of the volatiles by evaporation, the residue was azeotroped with toluene, triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 4-chloro-6-methoxy-7-(3-morpholinopropoxy)quinoline hydrochloride (240 mg, 93%).

1. temperaturewas heated
2. temperatureat reflux for 1 hour
3. customAfter removal of the volatiles
4. customby evaporation
5. customthe residue was azeotroped with toluene
6. customtriturated with ether
7. filtrationcollected by filtration
8. washwashed with ether
9. customdried under vacuum