反应详情

A solution of 6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)-1,4-dihydroquinolin-4-one (950 mg, 3.1 mmol) in thionyl chloride (25 ml) containing DMF (10 drops) was heated at reflux for 1.5 hours. After cooling, toluene was added and the volatiles were removed by evaporation. The residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 4-chloro-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinoline hydrochloride (1.23 g, 100%).

1. temperaturewas heated
2. temperatureat reflux for 1.5 hours
3. temperatureAfter cooling
4. customthe volatiles were removed by evaporation
5. customThe residue was triturated with ether
6. filtrationcollected by filtration
7. washwashed with ether
8. customdried under vacuum