HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,7-Dichloroquinoline → HCID 22646582, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,7-Dichloroquinoline | HCID 6866 | — |
| Reactant | 5-Amino-2-chloro-4-fluorophenol | HCID 158654 | — |
| Solvent | 2-Pentanol | HCID 22386 | — |
| Product | HCID 22646582 | HCID 22646582 | 79.8% |
Reaction Steps
Using an analogous procedure to that described for Example 15, 4,7-dichloroquinoline (198 mg, 1 mmol) was reacted with 4-chloro-2-fluoro-5-hydroxyaniline (194 mg, 1.2 mmol), (as described in EP 61741 A2), in 2-pentanol (5 ml) to give 7-chloro-4-(4-chloro-2-fluoro-5-hydroxyanilino)quinoline (258 mg, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809097B1 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-931a69c61529415189b3e377bfc6a9b7 |
| Source note | uspto-grants-2004_10 |