反应详情

A mixture of 4-chloro-6-cyano-7-(2-methoxyethoxy)quinoline hydrochloride (220 mg 0.84 mmol), (prepared as described for the starting material in Example 1), and 3-hydroxy-4-methylaniline (123 mg, 1 mmol) in isopropanol (10 ml) was heated at reflux for 1 hour. The mixture was allowed to cool, the solid product was collected by filtration, washed with acetone and dried to give 6-cyano-4-(3-hydroxy-4-methylanilino)-7-(2-methoxyethoxy)quinoline hydrochloride (210 mg, 60%) as an orange solid.

1. custom(prepared
2. temperaturewas heated
3. temperatureat reflux for 1 hour
4. temperatureto cool
5. filtrationthe solid product was collected by filtration
6. washwashed with acetone
7. customdried