反应详情

A mixture of 4-chloro-6-cyano-7-(2-methoxyethoxy)quinoline hydrochloride (300 mg 1 mmol), (prepared as described for the starting material in Example 1), and 4-chloro-2-fluoroaniline (0.5 ml, 3.4 mmol) in isopropanol (20 ml) was heated at reflux for 3 hours. The mixture was allowed to cool, the solid product was collected by filtration, washed with acetone and dried to give 4-(4-chloro-2-fluoroanilino)-6-cyano-7-(2-methoxyethoxy)quinoline hydrochloride (400 mg, 98%).

1. custom(prepared
2. temperaturewas heated
3. temperatureat reflux for 3 hours
4. temperatureto cool
5. filtrationthe solid product was collected by filtration
6. washwashed with acetone
7. customdried